Fresh Room Designs!



Welcome to the Holiday Inn SW Route 66!

Call us TODAY at (314) 821 – 6600 to book directly with us.


Guestrooms At-A-Glance

Our 213 newly renovated guestrooms.  Designed with style for your comfort and convenience. 

Holiday Inn Route 66 Double Queen Room

1. High-Efficiency Climate Control System
2. Simmons BeautyRest™ Signature Beds with Your Choice of “Firm” and “Soft” Pillows
3. Clock Radio and Landline Phone w/ Voicemail
4. Rolling Workstation Desk w/ Ergonomic Chair
5. Large HDTV with Digital Cablefree wifi
6. Personal Size Refrigerator
7. Hair Dryer / Iron (not pictured)
8. Coffee Maker

Swimming Pools

Enjoy a dip in either our indoor or outdoor pools or relax after a long day in our whirlpool.

Holiday Inn Route 66 Indoor Pool

Holiday Inn Route 66 Outdoor Pool

Pool & Hot Tub Hours: 8 am-10 pm
Outdoor Pool Open Seasonally.

Complimentary towels provided poolside.

Fitness Center

Holiday Inn Route 66 Fitness Center

get the TRUE Fitness AppOur fitness center sports state-of-the-art cardio equipment from TRUE. Link to your iPhone, monitor heart rate and customize your workouts through their easy to use controls. Stay motivated and track your workouts on your phone using TRUE’s Fitness App!

We also offer free weight dumbbells and yoga mats. Train hard, the hot tub is calling. 

Fitness Center Hours: 8 am-10 pm

On-Site Car Rental


For travelers needing transportation, look no further than the lobby.  That’s right we are on property!

To reserve a car visit the AVIS Website (Select “Holiday Inn Southwest” as your pickup location).

Holiday Inn SW, Route 66
10709 Watson Road
St. Louis, Mo 63127
(314) 821 – 6600

From I-44 take exit (277 B) south on (U.S. Route 61 / 67) also referred to as Lindbergh Boulevard to “right” on Watson Road (Route 66).

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Are you wanting to “Explore St. Louis”?

  • Simply (click once) on the “explore St. Louis” link below.

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