King Room at the New HI66


Dear Guest:

On behalf of the entire team, I would like to personally welcome your at the Holiday Inn SW – Route 66.


Our “STAR” Location is everything! 

Just 10 miles from Forest and 15 miles from downtown!

HI66 - St. Louis Map - with logo and star

  • Located (see the “yellow” star) in SW St. Louis County, in Sun Set Hills 
  • Minutes east from Interstates I-270 and 1/4 mile south of I-44
  • From I-44 take exit (277 B) south on (U.S. Route 61 / 67) also referred to as Lindbergh Boulevard to “right” on Watson Road (Route 66).

Value is everything:

  • Complimentary Wifi – Complimentary Business Center – Complimentary Self Parking – Complimentary indoor/outdoor pools – Complimentary Fitness Center

Price Guarantee:

  • “NEVER” pay more on another site for a room at our hotel.  We have a Best Price Guarantee – We guaranteed best available prices, or your first night is free

 Our newly renovated Lobby and Lobby Bar!

new HI66 Lobby Photo

More exciting changes are here…as one of the best known restaurant families in St. Louis, The Syberg family has opened a new bar and grill, the Twisted Tree Steakhouse which is connected to the hotel through our Event, Meeting and Banquet Center. 

Book a room, arrive, relax with a swim (indoor or out) or use the fitness center featuring TRUE equipment, have a lovely dinner and take the elevator home!   

A staycation is just the perfect touch for a special birthday, anniversary and/or just because! 

twisted tree - 3 photos in one - jpeg - final

Hours:  Opened Tuesday – Saturday (11:00 am to 10 pm)

Lunch:  From 11:00 am

Sip & Savor – Happy Hour:  From 3 pm and includes select wine, handcrafted cocktails and menu items ALL for $5.

Hotel Information:

  • 213 guestrooms (the largest Holiday Inn in St. Louis County) have been completely updated with new décor
  • (free Wifi and parking) and energy efficient lighting & comfort systems
  • We’ve added top-of-the-line beds in each room
  • We upgraded our “traditional desks” to rolling work stations, so you can be mobile and complete your work where you want.  
  • Twisted Tree (full menu) via room service from 4 pm to 9 pm Tuesday – Saturday.
  • TRUE Fitness equipment
  • Fully remodeled indoor and outdoor pools. 

Hosting a meeting or a special family event? 

  • 18,000 square feet of  flexible meeting/event, and banquet space (the largest of any Holiday Inn in St. Louis) 
  • Dedicated Catering & Event Managers

Event Concourse

You should never have to compromise quality for low price; at Holiday Inn Southwest – Route 66, you won’t have to. 


Terris Cooper, General Manager

Holiday Inn SW, Route 66
10709 Watson Road
St. Louis, Mo 63127
(314) 821 – 6600


We will strive to update all of the local events via the tab entitled “HOTEL” (on the next page).

  • At the bottom of the “HOTEL” (the next tab over) page we have listed all of the upcoming events, concerts, sports, etc., to keep you informed about all of the great things we have to offer in St. Louis.

Video Tour

Here is a video created by “Grain”.  I hope you enjoy it!

We are proud to partner with small start-up companies like Perfect 10 Foods.

See their journey as they travel the southeast staying at Holiday Inns while trying to grow their brand.

Our Green Initiative

learn more about Route 66