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10709 Watson Rd. St. Louis MO 63127             1 (314) 821-6600

Welcome to The Holiday Inn SW Route 66 Hotel & Conference Center!

Remodeled in 2016 and located on Lindbergh and Watson [Route 66] just off of I-270 and I-44, our unbeatable location, value, and amenities make the Holiday Inn St. Louis Southwest—Route 66 the perfect choice for your family vacation, business trip, or group event!

Book online or call us today at (314) 821-6600!

We guarantee the best available prices via our website or your first night is free!


Complimentary Amenities Included in Your Stay

  • Wifi
  • Business Center
  • Indoor/Outdoor Pools and Whirlpool
  • Fitness Center

Things to Do in St. Louis 

Free Activities




  • Soulard 
  • Downtown St. Louis
  • Central West End
  • Dogtown
  • The Grove
  • The Hill
  • Delmar Loop 
  • South Grand 

For Your Convenience:

  • On-site restaurant T-Bird Cafe for breakfast and Lobby Bar
  • Twisted Tree Steakhouse adjacent to our Banquet & Events Center
  • On-site Avis & Budget Car Rental Center

Our Banquet & Events Center includes:

  • 9 Meeting Rooms with 6000 square feet of pre-function space
  • Over 18,000 square feet of total event space–the most space of any Holiday Inn in St. Louis County

**Cancellation policy for guest rooms: Cancellations must be made by 4 p.m. the day prior to arrival. Thank you for understanding.

Indoor Pool – Click for More

learn more about Route 66 Our Green Initiative