King Room at the New HI66


Dear Guest:

On behalf of the entire team, I would like to personally welcome your at the Holiday Inn SW – Route 66.


Whether you are a first time visitor or repeat guest, I appreciate the opportunity to tell you more about our unique property conveniently located in SW St. Louis County, in Sun Set Hills, just minutes east from Interstates I-270 and 1/4 mile south of I-44, (Exit 277 B) just off of Lindbergh Boulevard.

I wanted to let you know that you will “NEVER” pay more on another site for a room at our hotel.

Book With Us Advantage

We will strive to update all of the local events via the tab entitled “HOTEL”.

At the bottom of the “HOTEL” page we have listed all of the upcoming events, concerts, sports, etc., to keep you informed about all of the great things we have to offer in St. Louis such as this:


Can’t make it to Munich this year? Come join us at the Anheuser-Busch St. Louis Brewery.  The party continues until October 3, so there is still plenty of time to plan your fall trip to St. Louis.

Throughout the month, visitors are invited to enjoy a variety of German-style beers and seasonal favorites, paired with traditional German fare such as bratwursts and Bavarian pretzels. Visitors can also participate in traditional German games and enjoy live German music and entertainment.


new HI66 Lobby Photo

More exciting changes are here…as one of the best known restaurant families in St. Louis, Sybergs has opened a new bar and grill, the Twisted Tree Steakhouse which is connected to the hotel through our Event, Meeting and Banquet Center. 

Book a room, arrive, relax with a swim (indoor or out) or use the fitness center featuring TRUE equipment, have a lovely dinner and take the elevator home!   

A staycation is just the perfect touch for a special birthday, anniversary and/or just because! 

twisted tree - 3 photos in one - jpeg - final

Hours:  Opened Tuesday – Saturday (11:00 am to 10 pm)

Lunch:  From 11:00 am

Sip & Savor – Happy Hour:  From 3 pm and includes select wine, handcrafted cocktails and menu items ALL for $5.

Did you know that all 213 guestrooms (the largest Holiday Inn in St. Louis County) have been completely updated with new décor (free Wifi and parking) and energy efficient lighting & comfort systems? 

We’ve added top-of-the-line beds in each room to ensure a good night’s rest and we also upgraded our “traditional desks” to rolling work stations, so you can be mobile and complete your work where you want.  We also serve Twisted Tree food via room service from 4 pm to 9 pm Tuesday – Saturday.

In addition, our fitness center features commercial grade TRUE Fitness equipment. However, if relaxation is what you’re looking for, be sure to check out our fully remodeled indoor and outdoor pools. 

Hosting a meeting or a special family event? We feature 18,000 square feet of e meeting/event and banquet space (the largest of any Holiday Inn in St. Louis) with our signature ballroom and flexible meeting rooms!

Event Concourse

Event Concourse

Our dedicated Catering and Event Managers will help design your menu to ensure that your event is not only flawless, but that it is memorable!

Whether you’re a seasoned “road warrior,” or family member spending quality time, we’re here to ensure the Holiday Inn tradition of gracious hospitality and efficient service.  You should never have to compromise quality for low price; at Holiday Inn Southwest – Route 66, you won’t have to. 


Terris Cooper, General Manager

Holiday Inn SW, Route 66
10709 Watson Road
St. Louis, Mo 63127
(314) 821 – 6600

From I-44 take exit (277 B) south on (U.S. Route 61 / 67) also referred to as Lindbergh Boulevard to “right” on Watson Road (Route 66).

Video Tour

Here is a video created by “Grain”.  I hope you enjoy it!

We are proud to partner with small start-up companies like Perfect 10 Foods.

See their journey as they travel the southeast staying at Holiday Inns while trying to grow their brand.

Our Green Initiative

learn more about Route 66