King Room at the New HI66



Dear Guest:

On behalf of the entire team, I would like to personally welcome your at the Holiday Inn SW – Route 66.

More exciting changes are here…as one of the best known restaurant families in St. Louis (Syberg) has opened a new bar and grill, the Twisted Tree Steakhouse which is connected to the hotel through our Event, Meeting and Banquet Center.   

Book a room, arrive, relax with a swim (indoor or out) or use the fitness center featuring TRUE equipment, have a lovely dinner and take the elevator home!   

A staycation is just the perfect touch for a special birthday, anniversary and/or just because!  (Dinner only until August)

twisted tree - 3 photos in one - jpeg - final

Whether you are a first time visitor or repeat guest, I appreciate the opportunity to tell you more about our unique property conveniently located in SW St. Louis County, in Sun Set Hills, just minutes east from Interstates I-270 and 1/4 mile south of I-44, (Exit 277 B) just off of Lindbergh Boulevard.

Our Holiday Inn has undergone a massive, multi-million dollar renovation that needs to be seen to be believed.   

Did you know that all 213 guestrooms (the largest Holiday Inn in St. Louis County) have been completely updated with new décor (free Wifi and parking) and energy efficient lighting & comfort systems? 

We’ve added top-of-the-line beds in each room to ensure a good night’s rest and we also upgraded our “traditional desks” to rolling work stations, so you can be mobile and complete your work where you want.  

In addition, our fitness center features commercial grade TRUE Fitness equipment. However, if relaxation is what you’re looking for, be sure to check out our fully remodeled indoor and outdoor pools. 

Hosting a meeting or a special family event? We feature 18,000 square feet of e meeting/event and banquet space (the largest of any Holiday Inn in St. Louis) with our signature ballroom and flexible meeting rooms! Our dedicated Catering and Event Managers will help design your menu to ensure that your event is not only flawless, but that it is memorable!

Whether you’re a seasoned “road warrior,” or family member spending quality time, we’re here to ensure the Holiday Inn tradition of gracious hospitality and efficient service.  You should never have to compromise quality for low price; at Holiday Inn Southwest – Route 66, you won’t have to. 


Terris Cooper, General Manager

Holiday Inn SW, Route 66
10709 Watson Road
St. Louis, Mo 63127
(314) 821 – 6600

From I-44 take exit (277 B) south on (U.S. Route 61 / 67) also referred to as Lindbergh Boulevard to “right” on Watson Road (Route 66).

Video Tour

We are proud to partner with small start-up companies like Perfect 10 Foods.

See their journey as they travel the southeast staying at Holiday Inns while trying to grow their brand.

Our Green Initiative

learn more about Route 66